Your Excel application is not able to communicate with other applications and the operating system.There is a possibility that your Excel application is corrupt and needs to be repaired before you can start opening Excel files again.If this is the case, most likely you will be able to open the Excel applications, but not a specific Excel file (or a new Excel file) There is a problematic add-in that is not allowing you to open Excel files.Since Excel is a tool that has to work seamlessly with other applications and operating systems, there are many things that can go wrong with it.Īnd of course, there is always a possibility that the Excel application in itself is the problem.īelow are some possible reasons due to which Microsoft Excel won’t open on your system: Possible Reasons Why Microsoft Excel Won’t Open Possible Reasons Why Microsoft Excel Won’t Open.