I have to run the OVRServer executable manually, but once I do that, everything except Unity works. I've been trying to get the Rift working in Unity on the Mac for a while now. I just want to make sure I'm not boneheading something before I submit a ticket. Hope that helps someone else! And thanks to thep3000 and BrotenTechCorp for the informative replies.
If you're getting the same problems that I did, use the latest patch, do NOT use the 'VR Supported' checkbox, and make sure that you install the runtime for each user who will use the Rift.